Web2 days ago · The mice were then injected with morphine (3.2 mg/kg s.c.), and mechanical thresholds were determined over a 3-hour time course. For CRISPR experiments, 4.5 μg of DNA were complexed with GenJet plus reagent in vivo transfection reagent (no. SL100500 from SignaGen) according to the manufacturer’s instructions and injected i.t. daily from … WebFeb 18, 2010 · Morphine (5 mg kg −1, i.p.) induced analgesia that was increased by fluoxetine (0.32 mg kg −1, i.p.). These results suggest that fluoxetine has an antinociceptive effect in tonic inflammatory pain through functional alteration of the serotonergic system and also potentiates the analgesic effect of morphine.
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