Tfr1 stearoylation
Web2 Jan 2024 · Previous studies have suggested that AP-1 facilitates transferrin receptor (TfR1) trafficking from the TGN to the cell membrane [ 17 – 20 ]. Here, we identify AP-1 and AP-2 as LZTFL1-interacting proteins and show that these interactions play an important role in membrane protein trafficking. Web15 Apr 2024 · TfR1 undergoes posttranslational modification by covalent attachment of S-acyl radicals to Cys62 and Cys67 via thioester bonds, with palmitate being the …
Tfr1 stearoylation
Did you know?
Webby the expression of transferrin receptor 1 (Tfr1) on those cells. Cell types with the highest expression of Tfr1 include erythroid precursors and dividing cells. When the iron binding sites on Tf are occupied or when Tf is absent iron introduced into plasma can enter cells through other transport systems (Hentze et al. 2010). Web1 Jul 2024 · Transferrin receptor1 (TfR1) is a type II transmembrane glycoprotein that involves intracellular uptake of iron. TfR1 is ubiquitously expressed at low levels in normal cells except erythroblasts and placental trophoblasts, which express high levels of TfR1 due to the need of up taking a large amount of iron.
Web5 Jan 2024 · P. vivax preferentially invades reticulocytes that express high levels of transferrin receptor 1 (TfR1 or CD71) ().TfR1 is an essential housekeeping protein involved in cellular transport of iron into cells through binding of iron-loaded transferrin (Tf) ().On circulating red blood cells, TfR1 is expressed only on reticulocytes and is progressively … WebDownloadable (with restrictions)! Mitochondria have essential functions within cells, and their dysfunction is linked to various disorders; here, the fatty acid stearic acid (C18:0), …
WebStearoylation is one of the numerous types of post-translational modification in proteins. Stearoylated proteins are involved in the regulation of cellular processes such as … Web13 Jun 2024 · The transferrin receptor (TfR1), which mediates cellular iron uptake through clathrin-dependent endocytosis of iron-loaded transferrin, plays a key role in iron …
WebTransferrin receptor 1. Transferrin receptor protein 1 ( TfR1 ), also known as C luster of D ifferentiation 71 ( CD71 ), is a protein that in humans is encoded by the TFRC gene. [5] [6] …
WebStearoylated by ZDHHC6 which inhibits TFRC-mediated activation of the JNK pathway and promotes mitochondrial fragmentation ( By similarity ). Stearoylation does not affect iron … chillin on a dirt road ice cold beer songWebTfR1 mutant animalshad gross respiratory defects in their DA neurons, manifesting in dysfunctional gene Fig. 1. Tfr1-mediated iron uptake is essential for the function of DA … grace on harrowWebTransferrin receptor protein 1, TR, TfR, TfR1, Trfr, T9, p90, CD71, Transferrin receptor protein 1, serum form, sTfR, TFRC Storage Store at 2 to 8°C.Antibody is stable for 24 months. chillin on the beach chairWeb19 Aug 2015 · The most stearoylated protein was TFR1, which is known to activate JNK. Whereas addition of the TFR1 ligand gambogic acid induced rapid, JNK-dependent … chillin on a dirt road songWebattached to TfR1 via a thioester bond in a post-translational modification called stearoylation, analogous to protein palmi-toylation by C16:0. This leads to reduced JNK … chillin on the moon cropped sweaterWeb11 Jul 2024 · The authors of the banana milkshake study argue that the mitochondrial fusion is due to stearoylation of an enzyme – TfR1 – that is involved in signalling pathways that … chillin on a sunday afternoonWeb6 May 2024 · Ferritin degradation via reduced Fth1 expression is associated with activation of ferroptosis, which is defined as ferritinophagy. 32 We believe that Tfr1 ablation in SCs … chillin on the farm 2022