Titin is a giant multi-functional sarcomeric filament that provides passive stiffness to cardiac myocytes. At its N terminus, titin is embedded in the Z-disk of the sarcomere. The rest of the molecule is divided between an elastic I-band region, a thick filament-binding A-band region, and the M-band region … See more The extensible I-band region of titin comprises 3 distinct elements: (1) tandem Ig segments that consist of serially-linked immunoglobulin(Ig)-like domains, (2) the springlike PEVK … See more It is well-known that post-translational modifications of contractile and regulatory proteins greatly affect cardiac function. Recent single molecule force spectroscopy studies of titin have discovered that … See more Therapeutic modalities targeting titin are at present largely theoretical, but the previous discussion suggests some possibilities for consideration. Increasing the expression of compliant N2BA titin or inducing the … See more Until recently, a small number of titin mutations had been documented in association with human cardiomyopathies.5,43–48 It was predicted that the … See more WebFeb 16, 2010 · The giant protein titin is thought to play major roles in the assembly and function of muscle sarcomeres. Structural details, such as widths of Z- and M-lines and …
BBC Radio 4 - The Adventures of Tintin : Herge - Archive
WebJan 27, 2024 · Titin adaptation to training and exercise Although titin has long been speculated to play a role in eccentric contraction and force enhancement ( Herzog and … WebApr 1, 2024 · Titin spans an entire half sarcomere from z-disk to m-line and its I-band region is composed of three domains: the proximal tandem Ig segment; the unique N2A (skeletal muscle), N2B (cardiac muscle), or N2BA (cardiac muscle) sequence; and the PEVK region ( Linke et al. 1996; Gregorio et al. 1999 ). hardground succession
The adaptation and changes of titin system following exercise …
WebSep 9, 2008 · In vertebrate muscle, the giant elastic protein titin is involved in strain sensing via its C-terminal kinase domain (TK) at the sarcomeric M-band and contributes to the … WebApr 8, 2024 · A talented CG animator currently working on the Ahsoka Disney+ series made a stunning live-action fan film of Attack on Titan. Masashi Imagawa, a CG artist and generalist at Industrial Light & Magic, recreated the Attack of Titan anime series as a live-action movie. Per Anime Senpai, Imagawa uploaded a half-a-minute clip of a live-action fan ... change cabin filter smell